POSITIVe Publications
Addressing the inter-individual variation in response to consumption of plant food bioactives - towards a better understanding of their role in healthy ageing and cardiometabolic risk reduction. Manach C, Milenkovic D, Van de Wiele T, Rodriguez-Mateos A, de Roos B, Garcia-Conesa MT, Landberg R, Gibney ER, Heinonen M, Tomás-Barberán F, Morand C. Mol Nutr Food Res. 2016 Sep 30. doi: 10.1002/mnfr.201600557. [Epub ahead of print] Review. PubMed |
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Impact of Flavanols on Cardiometabolic Biomarkers: a meta-analysis of randomized controlled human trials to explore the role of inter-individual variability. Menezes R, Rodriguez-Mateos A, Kalsatou A, Gonzalez-Sarrias A, Greyling A, Giannaki C, Andres-Lacueva C, Milenkovic D, Gibney E.R, Dumont J, Schär M, Garcia-Aloy M, Palma-Duran S A, Ruskovska T, Maksimova V, Combet E, Pinto P. Nutrients2017, 9(2), 117; doi:10.3390/nu9020117 |
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Host-related factors explaining interindividual variability of carotenoid bioavailability and tissue concentrations in humans. T. Bohn, C. Desmarchelier, L.O. Dragsted, C.S. Nielsen, W. Stahl, R. Rühl, J. Keijer, P. Borel. Mol Nutr Food Res. 2017 Jan 19. doi: 10.1002/mnfr.201600685 |
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Interindividual Variability in Biomarkers of Cardiometabolic Health after Consumption of Major Plant-Food Bioactive Compounds and the Determinants Involved. Milenkovic D, Morand C, Cassidy A, Konic-Ristic A, Tomás-Barberán F, Ordovas JM, Kroon P, De Caterina R, Rodriguez-Mateos A. Adv Nutr. 2017 Jul 14;8(4):558-570. doi: 10.3945/an.116.013623. Open Access |
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A Systematic Review and Meta-Analysis of the Effects of Flavanol-Containing Tea, Cocoa and Apple Products on Body Composition and Blood Lipids: Exploring the Factors Responsible for Variability in Their Efficacy. Antonio González-Sarrías, Emilie Combet, Paula Pinto, Pedro Mena, Margherita Dall’Asta, Mar Garcia-Aloy, Ana Rodríguez-Mateos, Eileen R. Gibney, Julie Dumont, Marika Massaro, Julio Sánchez-Meca, Christine Morand and María-Teresa García-Cones. Nutrients2017 doi: 10.3390/nu9070746 Open Access |
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Bioavailability of Quercetin in Humans with a focus on inteindividual variation. A.Filipa Almeida, Grethe Iren A. Borge, Mariusz Piskula, Adriana Tudose, Liliana Tudoreanu, Katerine Valentova, Gary Williamson, Claudia N. Santos. Comprehensice Reviews in Food Science and Food Safety. 2018 doi: 10.1111/1541-4337.12342 Open Access |
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Meta-Analysis of the Effects of Foods and Derived Products Containing Ellagitannins and Anthocyanins on Cardiometabolic Biomarkers: Analysis of Factors Influencing Variability of the Individual Responses. María-Teresa García-Conesa,Karen Chambers,Emilie Combet,Paula Pinto,Mar Garcia-Aloy,Cristina Andrés-Lacueva,Sonia de Pascual-Teresa,Pedro Mena,Aleksandra Konic Ristic,Wendy J. Hollands,Paul A. Kroon,Ana Rodríguez-Mateos,Geoffrey Istas,Christos A. Kontogiorgis,Dilip K. Rai,Eileen R. Gibney,Christine Morand,Juan Carlos Espín and Antonio González-Sarrías. Int. J. Mol. Sci. 2018, 19(3), 694; doi: 10.3390/ijms19030694 Open Access |
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Interlaboratory coverage test on plant food bioactive compounds and their metabolites by mass spectrometry-based untargeted metabolomics. Koistinen VM, Bento da Silva A, Abrankó L, Low D, Garcia Villalba R, Tomás Barberán F, Landberg R, Savolainen O, Alvarez-Acero I, de Pascual-Teresa S, Van Poucke C, Almeida C, Petrásková L, Valentová K, Durand S, Wiczkowski W, Szawara-Nowak D, González-DomínguezR, Llorach R, Andrés-Lacueva C, Aura AM, Seppänen-Laakso T, Hanhineva K, Manach C, Bronze MR , Accepted in Metabolites 2018 doi : 10.3390/metabo8030046 Open Access |
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Breakthroughs in the health effects of plant food bioactives: a perspective on microbiomics, nutri(epi)genomics, and metabolomics. Bayram B, Gonzalez-Sarrias A, Istas G, Garcia-Aloy M , Morand C, Tuohy K, Garcia-Villalba R, Mena P, Accepted in Journal of Agricultural and Food Chemistry doi: 10.1021/acs.jafc.8b03385 Open Access |
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β-Carotene in the Human Body – Metabolic Bioactivation Pathways - from Digestion to Tissue Distribution and Excretion Torsten Bohn1, Charles Desmarchelier2, Sedef N. El3, Jaap Keijer4, Evert van Schothorst44 , Ralph Rühl5,*, Patrick Borel2. Proceedings of the Nutrition Society 2019 Feb;78(1):68-87. doi: 10.1017/S0029665118002641 Link |
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Factors Explaining Interpersonal Variation in Plasma Enterolactone Concentrations in Humans - Elin Hålldin, Anne Kirstine Eriksen, Carl Brunius, Andreia Bento da Silva, Maria Bronze, Kati Hanhineva, Anna-Marja Aura and Rikard Landberg. Mol Nutr Food Res. 2019 Aug;63(16):e1801159 Link |
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Factors affecting intake, metabolism and health benefits of phenolic acids – Do we understand individual variability? Andreia Bento-Silva, Ville M. Koistinen, Pedro Mena, Maria Bronze, Kati Hanhineva, Stefan Sahlström, Vaida Kitryte, Sofia Moco, Anna-Marja Aura. Eur J Nutr. 2019 May 21. doi: 10.1007/s00394-019-01987-6. Link | |
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Interindividual Variability in Absorption, Distribution, Metabolism, and Excretion of Food Phytochemicals Should Be Reported. Morand C, Tomás-Barberán FA. J Agric Food Chem. 2019 Apr 10;67(14):3843-3844. Link |
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Improving the reporting quality of intervention trials addressing the inter-individual variability in response to the consumption of plant bioactives: quality index and recommendations. Nikolic et al.Eur J Nutr. 2019 Sep 6. doi: 10.1007/s00394-019-02069-3. Link |
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Factors influencing the cardiometabolic response to (poly)phenols and phytosterols: a review of the COST Action POSITIVe activities. Gibney ER, Milenkovic D, Combet E, Ruskovska T, Greyling A, González-Sarrías A, de Roos B, Tomás-Barberán F, Morand C, Rodriguez-Mateos A. Eur J Nutr. 2019 Sep 6. doi: 10.1007/s00394-019-02066-6. Link |
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Impact of Foods and Dietary Supplements Containing Hydroxycinnamic Acids on Cardiometabolic Biomarkers: A Systematic Review to Explore Inter-Individual Variability. Martini D, Chiavaroli L, González-Sarrías A, Bresciani L, Palma-Duran SA, Dall'Asta M, Deligiannidou GE, Massaro M, Scoditti E, Combet E, Maksimova V, Urpi-Sarda M, Kontogiorgis CA, Andrés-Lacueva C, Gibney ER, Del Rio D, Morand C, Garcia-Aloy M, Rodriguez-Mateos A, Mena P. Nutrients. 2019 Aug 5;11(8). pii: E1805. doi: 10.3390/nu11081805. Review. Link |
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Contribution of plant food bioactives in promoting health effects of plant foods: why look at interindividual variability? Morand C, Tomás-Barberán FA. Eur J Nutr. 2019 Oct 22. doi: 10.1007/s00394-019-02096-0. [Epub ahead of print] Review. https://link.springer.com/article/10.1007/s00394-019-02096-0 |
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Future prospects for dissecting inter-individual variability in the absorption, distribution and elimination of plant bioactives of relevance for cardiometabolic endpoints. Landberg R, Manach C, Kerckhof FM, Minihane AM, Saleh RNM, De Roos B, Tomas-Barberan F, Morand C, Van de Wiele T. Eur J Nutr. 2019Oct 23. doi: 10.1007/s00394-019-02095-1. [Epub ahead of print] Review. https://link.springer.com/article/10.1007/s00394-019-02095-1 |
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Targeting the delivery of dietary plant bioactives to those who would benefit most: from science to practical applications. de Roos B, Aura AM, Bronze M, Cassidy A, Conesa MG, Gibney ER, Greyling A, Kaput J, Kerem Z, Knežević N, Kroon P, Landberg R, Manach C, Milenkovic D, Rodriguez-Mateos A, Tomás-Barberán FA, van de Wiele T, Morand C. Eur J Nutr. 2019 Oct 22. doi: 10.1007/s00394-019-02075-5. [Epub ahead of print] Review., https://link.springer.com/article/10.1007/s00394-019-02075-5 |
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A Review of Factors Affecting Anthocyanin Bioavailability: Possible Implications for the Inter-Individual Variability.Eker ME, Aaby K, Budic-Leto I, et al. Foods. 2019;9(1):2. Published 2019 Dec 18. doi:10.3390/foods9010002 LINK |
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Polyphenols in human nutrition: from the in vitro antioxidant capacity to the beneficial effects on cardiometabolic health and related inter-individual variability – an overview and perspective. T. Ruskovska, V. Maksimova and D. Milenkovic. DOI: https://doi.org/10.1017/S0007114519002733 |
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Why interindividual variation in response to consumption of plant food bioactives matters for future personalised nutrition. Morand C, De Roos B, Garcia-Conesa MT, et al. Proc Nutr Soc. 2020;79(2):225-235. doi:10.1017/S0029665120000014 LINK | |
Other Outcomes
The metabolic pathway of flavan-3-ols (also known as flavanols) in humans. Eirini Deligiannidou, Egon Willighagen, Denise Slenter. Description: Flavanols are derivatives of flavans and include catechin, epicatechin gallate, epigallocatechin, epigallocatechin gallate, proanthocyanidins, theaflavins, thearubigins. These compounds differ considerably not only in their structural and functional properties, but also in their metabolism and bioavailability. Green arrows indicate microbiota-mediated steps, and Red arrows represent mammalian enzyme-mediated conversions. Pink arrows indicate steps that can be both microbiota- or enzyme-mediated. This pathway was developed based upon 22 papers, therefore black arrows indicate missing information regarding the nature of conversion. | Link to Wikipathways |
Publications from partners with acknowledgment to COST POSITIVe FA1403
WG1 related papers
Untargeted 1H NMR-Based Metabolomics Analysis of Urine and Serum Profiles after Consumption of Lentils, Chickpeas, and Beans: An Extended Meal Study To Discover Dietary Biomarkers of Pulses. Madrid-Gambin F, Brunius C, Garcia-Aloy M, Estruel-Amades, Landberg R, Andres-Lacueva C. J Agric Food Chem. 2018 Jul 11;66(27):6997-7005. doi: 10.1021/acs.jafc.8b00047. Epub 2018 Jul 2.
The gut microbiota urolithin metabotypes revisited: The human metabolism of ellagic acid is mainly determined by aging. Cortés-Martín, A.; García-Villalba, R.; González-Sarrías, A., Romo-Vaquero, M.; Loria-Kohen, V.; Ramirez de Molina, A.; Tomas-Barberan, F.A.; Selma, M.V.; Espín, J.C.. Food & Funct 2018, 9, 4100-4106. doi.org/10.1039/c8fo00956b
Polyphenols gut microbiota metabolites: Bioactives or Biomarkers? Tomas-Barberan, F.A.; Selma, M.V.; Espin, J.C. J. Agric. Food Chem. 2018, 66, 3593-3594. doi: 10.1021/acs.jafc.8b00827
In vitro gut metabolism of [U-13C]-quinic acid, the other hydrolysis product of chlorogenic acid. M. Naranjo Pinta, I. Montoliu, A.-M. Aura, T. Seppänen-Laakso, D. Barron, S. Moco Molecular Nutrition and Food Research, (2018) 62: 1800396. doi: 10.1002/mnfr.201800396.
Microbial and endogenous metabolic conversions of rye phytochemicals. Koistinen, Ville M., and Kati Hanhineva. Molecular nutrition & food research 61.7 (2017): 1600627. doi: 10.1002/mnfr.201600627.
Targeted and Untargeted Metabolomics to Explore the Bioavailability of the Secoiridoids from a Seed/Fruit Extract (Fraxinus angustifolia Vahl) in Human Healthy Volunteers: A Preliminary Study. Rocío García-Villalba, Francisco A. Tomás-Barberán, Pascale Fança-Berthon, Marc Roller, Pilar Zafrilla, Nicolas Issaly and María-Teresa García-Conesa. Molecules 2015, 20, 22202–22219. Abstract
Influence of age on the absorption, metabolism, and excretion of cocoa flavanols in healthy subjects. Ana Rodriguez-Mateos, Tania Cifuentes-Gomez, Isidro Gonzalez-Salvador, Javier I. Ottaviani, Hagen Schroeter, Malte Kelm, Christian Heiss and Jeremy P. E. Spencer. Mol. Nutr. Food Res. 2015; DOI: 10.1002/mnfr.201500091 Abstract
Plasma and Urinary Phenolic Profiles after Acute and Repetitive Intake of Wild Blueberry. Rodrigo P. Feliciano, Geoffrey Istas, Christian Heiss and Ana Rodriguez-Mateos. Molecules2016, 21, 1120. doi: 10.3390/molecules21091120 Abstract
Bioavailability of wild blueberry (poly)phenols at different levels of intake. Rodriguez-Mateos A, Feliciano RP, Cifuentes-Gomez T and Spencer JPE. J Berry Res2016; 6(2), 137-148. doi: 10.3233/JBR-160123 Abstract
Development and validation of a high-throughput micro solid-phase extraction method coupled with ultra-high-performance liquid chromatography-quadrupole time-of-flight mass spectrometry for rapid identification and quantification of phenolic metabolites in human plasma and urine. Feliciano RP, Mecha E, Bronze MR, Rodriguez-Mateos A. J Chromatogr A. 2016 Sep 16; 1464:21-31. doi: 10.1016/j.chroma.2016.08.027 Abstract
Identification and quantification of novel cranberry-derived plasma and urinary (poly)phenols. Feliciano RP, Boeres A, Massacessi L, Istas G, Ventura MR, Nunes Dos Santos C, Heiss C, Rodriguez-Mateos A. Arch Biochem Biophys. 2016; 599:31-41. doi: 10.1016/j.abb.2016.01.014 Abstract
Urolithins, the rescue of 'old' metabolites to understand a 'new' concept: metabotypes as a nexus between phenolic metabolism, microbiota dysbiosis and host health status. Tomás-Barberán FA, González-Sarrías A, García-Villalba R, Núñez-Sánchez MA, Selma MV, García-Conesa MT, Espín JC. Mol Nutr Food Res. 2016 May 9. doi: 10.1002/mnfr.201500901. Abstract
Resveratrol metabolite profiling in clinical nutrition research--from diet to uncovering disease risk biomarkers: epidemiological evidence. Rabassa M, Zamora-Ros R, Urpi-Sarda M, Andres-Lacueva C. Ann N Y Acad Sci.2015; 1348(1):107-15. doi: 10.1111/nyas.12851 Abstract
The role of metabolism (and the microbiome) in defining the clinical efficacy of dietary flavonoids, Cassidy A and Minihane AM, Am J Clin Nutr, in press, Abstract
WG2 related papers
A systems biology network analysis of nutri(epi)genomic changes in endothelial cells exposed to epicatechin metabolites. Milenkovic D, vanden Berghe W, Morand C, Claude S, van de Sandt A, Gorressen S, Monfoulet LE, Chirumamilla C, Declerck K, Szarc vel Szic K, Lahtela-Kakkonen M, Gerhauser C, Merx M, Kelm M. Scientific Report (2018) , in press
Plasma urolithin metabolites correlate with improvements in endothelial function after red raspberry consumption: a double-blind randomized controlled trial. Istas, G.; Feliciano, R.P.; Weber, T.; García-Villalba, R.; Tomas-Barberan, F.; Heiss, C.; Rodriguez-Mateos, A. Archives of Biochemistry and Biophysics. 2018, 651, 43-51. doi.org/10.1016/j.abb.2018.05.016
A computational analysis of the polyphenol-protein interactome. S. Lacroix, J. Klicic Badoux, M.-P. Scott-Boyer, S. Parolo, A. Matone, C. Priami, M.J. Morine, J. Kaput, S. Moco. Scientific Reports, (2018) 8(1): 2232. doi: 10.1038/s41598-018-20625-5.
An Exploratory Search for Potential Molecular Targets Responsive to the Probiotic Lactobacillus salivarius PS2 in Women With Mastitis: Gene Expression Profiling vs. Interindividual Variability. Javier De Andres , Esther Jimenez Quintana, Irene Espinosa-Martos , Juan Miguel Rodriguez and María Teresa García-Conesa* Front. Microbiol. 2018, 9:2166, doi: 10.3389/fmicb.2018.02166
Back to the future: Epigenetic clock plasticity towards healthy aging. Declerck K1, Vanden Berghe W2.Mech Ageing Dev. 2018 Jan 11. pii: S0047-6374(17)30247-6. doi: 10.1016/j.mad.2018.01.002. [Epub ahead of print]
Critical Evaluation of Gene Expression Changes in Human Tissues in Response to Supplementation with Dietary Bioactive Compounds: Moving Towards Better-Quality Studies. Pokimica B, García-Conesa MT. Nutrients. 2018 Jun 22;10(7). pii: E807. doi: 10.3390/nu10070807. Review.
Non-extractable polyphenols produce gut microbiota metabolites that persist in circulation and show anti-inflammatory and free radical-scavenging effects. González-Sarrías, A.; Espín, J.C.; Tomas-Barberan, F.A. Trends Food Sci. Technol. 2017, 69, 281-288. doi.org/10.1016/j.tifs.2017.07.010.
The gut microbiota: a key factor in the therapeutic effects of (poly)phenols. Espin, J.C.; Gonzalez-Sarrias, A.; Tomas-Barberan, F.A. Biochem. Pharmacol. 2017, 139, 82-93. doi: 10.1016/j.bcp.2017.04.033
Clustering according to urolithin metabotype explains the interindividual variability in the improvement of cardiovascular risk biomarkers in overweight-obese individuals consuming pomegranate: A randomized clinical trial. González-Sarrías, A., García-Villalba, R.; Romo-Vaquero, M.; Alasarvar, C.; Örem, A.; Zafrilla, P.; Tomás-Barberán, F.A.; Selma, M.V.; Espin, J.C. Mol. Nutr. Food Res., 2017, 61 (5), doi: 10.1002/mnfr.201600830.
Acute intake of curcumin differently affects endothelial function and nutrigenomic response in male and female smokers: a randomized controlled trial. Barber-Chamoux N, Milenkovic D, Verny MA, Habauzit V, Pereira B, Richard D, Mazur A, Lusson JR, Dubray C, Morand C. Molecular Nutrition and Food Research 2017 Oct 15
Curcumin modulates endothelial permeability and monocyte transendothelial migration by affecting endothelial cell dynamics. Monfoulet LE, Mercier S, Bayle D, Tamaian R, Barber-Chamoux N, Morand C, Milenkovic D. Free radical biology & medicine. 2017; 112:109-120
Effects of age and soybean isoflavones on hepatic cholesterol metabolism and thyroid Hormone availability in acyclic female rats. Šošić-Jurjević B, Lütjohann D, Jarić I, Miler M, Vojnović Milutinović D, Filipović B, Ajdžanović V, Renko K, Wirth EK, Janković S, Kӧhrle J, Milošević V. Exp Gerontol. 2017 Jun;92:74-81. Abstract
Role of sulfotransferases in resveratrol metabolism in human adipocytes. N. Gheldof, S. Moco, C. Chabert, T. Teav, D. Barron, and J. Hager (2017) , Molecular Nutrition and Food Research, 61 (10). Abstract
Cocoa flavanol intake improves endothelial function and Framingham Risk Score in healthy men and women: a randomised, controlled, double-masked trial: the Flaviola Health Study. Roberto Sansone, Ana Rodriguez-Mateos, Jan Heuel, David Falk, Dominik Schuler, Rabea Wagstaff, Gunter G. C. Kuhnle, Jeremy P. E. Spencer, Hagen Schroeter, Marc W. Merx, Malte Kelm, Christian Heiss and for the Flaviola Consortium, European Union 7th Framework Program. British Journal of Nutrition 2016 114(08):1246-1255. Abstract
Interactions of gut microbiota with dietary polyphenols and consequences to human health. Tomás-Barberán, F.A.; Selma, M.V.; Espín, J.C. Curr. Opin. Clin. Nut. Metab. Care, 2016, 19: 471-476. DOI: 10.1097/MCO.0000000000000314.
Epigenetic Control of Cardiovascular Health by Nutritional Polyphenols Involves Multiple Chromatin-Modifying Writer-Reader-Eraser Proteins. K. Declerck, K. Szarc vel Szic, A. Palagani, K. Heyninc, G. Haegeman,Ch. Morand, D. Milenkovic and W. Vanden Berghe. Current Topics in Medicinal Chemistry 2016. Abstract
From inflammaging to healthy aging by dietary lifestyle choices: is epigenetics the key to personalized nutrition? K. Szarc vel Szic, K. Declerck, M. Vidakovic, W. Vanden Berghe. Clinical Epigenetics 2015, 7:33. DOI:10.1186/s13148-015-0068-2 Abstract
Flavonoid intake and cardiovascular disease risk. Rodrigo P Feliciano, Sarah Pritzel, Christian Heiss and Ana Rodriguez-Mateos. Current Opinion in Food Science 2015, 2:92–99. DOI:10.1016/j.cofs.2015.02.006 Abstract
Impact of cocoa flavanol intake on age-dependent vascular stiffness in healthy men: a randomized, controlled, double-masked trial. Christian Heiss, Roberto Sansone, Hakima Karimi, Moritz Krabbe, Dominik Schuler, Ana Rodriguez-Mateos, Thomas Kraemer, Miriam Margherita Cortese-Krott, Gunter G. C. Kuhnle, Jeremy P. E. Spencer, Hagen Schroeter, Marc W. Merx, Malte Kelm. AGE 2015,37:56. DOI:10.1007/s11357-015-9794-9 Abstract
Direct comparison of metabolic health effects of the flavonoids quercetin, hesperetin, epicatechin, apigenin and anthocyanins in high-fat-diet-fed mice. Elise F. Hoek-van den Hil, Evert M. van Schothorst, Inge van der Stelt, Hans J. M. Swarts, Marjanne van Vliet, Tom Amolo, Jacques J. M. Vervoort, Dini Venema, Peter C. H. Hollman, Ivonne M. C. M. Rietjens, Jaap Keijer. Genes Nutr 2015,10:23. DOI:10.1007/s12263-015-0469-z Abstract
Citrus flavanones naringenin and hesperetin improve antioxidant status and membrane lipid compositions in the liver of old-aged Wistar rats. Marko Miler, Jasmina Živanović, Vladimir Ajdžanović, Zorana Oreščanin-Dušić, Dragan Milenković, Aleksandra Konić-Ristić, Duško Blagojević, Verica Milošević, Branka Šošić-Jurjević. Experimental Gerontology 84 (2016) 49–60. doi: 10.1016/j.exger.2016.08.014 Abstract
Functional morphology of pituitary -thyroid and -adrenocortical axes in middle-aged male rats treated with Vitex agnus castus essential oil. BrankaˇSoˇsi´c-Jurjevi´, Vladimir Ajdˇzanovi´, Branko Filipovi´, Svetlana Trifunovi´, Ivana Jari´, Nataˇsa Risti´, Verica Miloˇsevi´. Acta Histochemica (2016), DOI: 10.1016/j.acthis.2016.07.007.
An update on the role of nutrigenomic modulations in mediating the cardiovascular protective effect of fruit polyphenols. I. Krga, D. Milenkovic, C. Morand and L.-E. Monfoulet. Food Funct.,2016, DOI: 10.1039/c6fo00596a. doi: 10.1039/c6fo00596a Abstract
Histological study of the ovaries from the superovulated mouse supplemented by bioactive feed additive. Vanya Mladenova, Desislava Abadjieva, Elena Kistanova. Journal of Mountain Agriculture on the Balkans, vol. 19, 2, 2016, (23-36).
Cranberry (poly)phenol metabolites correlate with improvements in vascular function: A double-blind, randomized, controlled, dose-response, crossover study.Rodriguez-Mateos A, Feliciano RP, Boeres A, Weber T, Dos Santos CN, Ventura MR, Heiss C. Mol Nutr Food Res. 2016; 60(10):2130-2140. doi: 10.1002/mnfr.201600250 Abstract
Other recent articles published by POSITIVe partners with POSITIVe acknowledgement.
9-Cis-13,14-dihydroretinoic acid, a new endogenous mammalian ligand of retinoid X receptor and the active ligand of a potential new vitamin A category: vitamin A. Ralph Rühl, Wojciech Krezel, and Angel R. de Lera. Nutrition Reviews, (2018) doi: 10.1093/nutrit/nuy057
Menstrual cycle rhythmicity: metabolic patterns in healthy women C.F. Draper, K. Duisters, B. Weger, A. Chakrabarti, A.C. Harms, L. Brennan, T. Hankemeier, L. Goulet, T. Konz, F.P. Martin, S. Moco, J. van der Greef Scientific Reports, (2018), 8: 14568; DOI: 10.1038/s41598-018-32647-0.
The phytoestrogen genistein prevents trabecular bone loss and affects thyroid follicular cells in a male rat model of osteoporosis. Filipović B, Šošić-Jurjević B, Ajdžanović V, Živanović J, Manojlović-Stojanoski M,Nestorović N, Ristić N, Trifunović S, Milošević V. J Anat. 2018, 233(2):204-212. doi: 10.1111/joa.12828.
Somatopause, weaknesses of the therapeutic approaches and the cautious optimism based on experimental ageing studies with soy isoflavones. Ajdžanovic VZ, Trifunovic S, Miljic D, Šošic-Jurjevic B, Filipovic B, Miler M , Ristic N, Manojlovic-Stojanoski M, Miloševic V.. EXCLI J. 2018, 17:279-301. doi: 10.17179/excli2017-956.
Soy isoflavone effects on the adrenal glands of orchidectomized adult male rats: a comprehensive histological and hormonal study Milošević VL, Severs WB, Ristić NM, Manojlović-Stojanoski MN, Popovska-Perčinić FV, Šošić-Jurjević BT, Pendovski LB, Trifunović SL, Miler MŠ, Ajdžanović VZ.. Histol Histopathol. 2018, 33(8):843-857. doi: 10.14670/HH-11-984.
(Poly)phenol-digested metabolites modulate alpha-synuclein toxicity by regulated proteostasis. Macedo, D.; Jardim, C.; Figueira, I.; Almeida, F.; McDougall, G.J.; Stewart, D.; Yuste, J.E.; Tomás-Barberán, F.A.; Tenreiro, S.; Outeiro, T.F.; Santos, C.N. Sci. Rep. 2018, DOI: 10.1038/s41598-018-25118-z.
Bioaccessibility and inhibitory effects on digestive enzymes of carnosic acid in sage and rosemary. Pınar Ercan, Sedef Nehir El, International Journal of Biological Macromolecules 115 (2018) 933–939. doi: 10.1016/j.ijbiomac.2018.04.139.
Arthrospira (Spirulina) platensis supplementation affects folliculogenesis, progesterone and ghrelin levels in fattening pre-pubertal gilts. Abadjieva D, Nedeva R., Marchev Y., G. Jordanova, Chervenkov M., J. Dineva, Shumkis A., Shimkine A., Teerds K., Kistanova E. Journal of Applied Phycology,2018,30(1):445-452. ISSN:0921-8971, DOI:10.1007/s10811-017-1263-7, IF:2.616 ( in collaboration with member of COST Action FA1403 team from Wageningen University, the Netherlands - K.Teerds )
Transgenerational beneficial effect of Arthrospira (Spirulina) platensis on the rabbit ovaries . Abadjieva, D., Shimkus, A., Shimkiene, A., Rashev, P., Kistanova, E. Journal of Applied Phycology, 2018, 30(3): 1691-1700. DOI 10.1007/s10811-018-1400-y IF:2.616
Oregonin from Alnus incana bark affects DNA methyltransferases expression and mitochondrial DNA copies in mouse embryonic fibroblasts. Jelena Krasilnikova, Liga Lauberte, Elena Stoyanova, Desislava Abadjieva, Mihail Chervenkov, Mattia Mori, Elisa De Paolis, Vanya Mladenova, Galina Telysheva, Bruno Botta & Elena Kistanova. Journal of Enzyme Inhibition and Medicinal Chemistry, 2018, 33:1, 1055-1063, DOI: 10.1080/14756366.2018.1476504, SJR-1,04; IF 3,638 (in collaboration with member of COST Action FA1403 team from Latvia - J.Krasilnikova and members of COST Action CA15135 - B.Botta, M.Mori).
Effect of Melissa officinalis L. on the level of induced lipid peroxidation in mouse liver. Chervenkov M., T. Ivanova, E. Stoyanova, A. Alexandrova, E. Tzvetanova, L. Tancheva, A. Georgieva, E. Kistanova. Bulgarian Chemical Communications, 2018, 50(C):48-51. SJR- 0,156. IF:0,242
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Gene expression changes in colon tissues from colorectal cancer patients following the intake of an ellagitannin-containing pomegranate extract: a randomized clinical trial. María A. Nuñez-Sánchez, Antonio González-Sarrías, Rocío García-Villalba, Tamara Monedero-Saiz, b, Noelia V. García-Talavera, María B. Gómez-Sánchez, Carmen Sánchez-Álvarez, Ana M. García-Albert, Francisco J. Rodríguez-Gil, Miguel Ruiz-Marín, Francisco A. Pastor-Quirante, Francisco Martínez-Díaz, Francisco A. Tomás-Barberán, Juan Carlos Espín, María-Teresa García-Conesa. Journal of Nutritionnal Biochemistry 2017, 42: 126-133 Abstract
Comprehensive characterization of the effects of ellagic acid and urolithins on colorectal cancer and key-associated molecular hallmarks: MicroRNA cell specific induction of CDKN1A (p21) as a common mechanism involved. Antonio González-Sarrías, María Angeles Núñez-Sánchez, Joao Tome-Carneiro, Francisco A. Tomás-Barberán, María Teresa García-Conesa and Juan Carlos Espín, Mol. Nutr. Food Res.2016, 60, 701–716. doi: 10.1002/mnfr.201500780
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