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POSITIVe publications on research conducted through partnerships will be listed below.

Action Publications

Addressing the inter-individual variation in response to consumption of plant food bioactives - towards a better understanding of their role in healthy ageing and cardiometabolic risk reduction. Manach C, Milenkovic D, Van de Wiele T, Rodriguez-Mateos A, de Roos B, Garcia-Conesa MT, Landberg R, Gibney ER, Heinonen M, Tomás-Barberán F, Morand C. Mol Nutr Food Res. 2016 Sep 30. doi: 10.1002/mnfr.201600557. [Epub ahead of print] Review. PubMed

MNFR 2017 Graphical Abstract

Impact of Flavanols on Cardiometabolic Biomarkers: a meta-analysis of randomized controlled human trials to explore the role of inter-individual variability. Menezes R, Rodriguez-Mateos A, Kalsatou A, Gonzalez-Sarrias A, Greyling A, Giannaki C, Andres-Lacueva C, Milenkovic D, Gibney E.R, Dumont J, Schär M, Garcia-Aloy M, Palma-Duran S A, Ruskovska T, Maksimova V, Combet E, Pinto P. Nutrients2017, 9(2), 117; doi:10.3390/nu9020117

Publication with COST POSITIVe acknowledgment

WG1: Inter-individual variation in bioavailability

Targeted and Untargeted Metabolomics to Explore the Bioavailability of the Secoiridoids from a Seed/Fruit Extract (Fraxinus angustifolia Vahl) in Human Healthy Volunteers: A Preliminary Study. Rocío García-Villalba, Francisco A. Tomás-Barberán, Pascale Fança-Berthon, Marc Roller, Pilar Zafrilla, Nicolas Issaly and María-Teresa García-Conesa. Molecules2015, 20, 22202–22219. Abstract

Influence of age on the absorption, metabolism, and excretion of cocoa flavanols in healthy subjects. Ana Rodriguez-Mateos, Tania Cifuentes-Gomez, Isidro Gonzalez-Salvador, Javier I. Ottaviani, Hagen Schroeter, Malte Kelm, Christian Heiss and Jeremy P. E. Spencer. Mol. Nutr. Food Res.2015; DOI: 10.1002/mnfr.201500091 Abstract

Plasma and Urinary Phenolic Profiles after Acute and Repetitive Intake of Wild Blueberry. Rodrigo P. Feliciano, Geoffrey Istas, Christian Heiss and Ana Rodriguez-Mateos. Molecules2016, 21, 1120. doi: 10.3390/molecules21091120 Abstract

Bioavailability of wild blueberry (poly)phenols at different levels of intake. Rodriguez-Mateos A, Feliciano RP, Cifuentes-Gomez T and Spencer JPE. J Berry Res2016; 6(2), 137-148. doi: 10.3233/JBR-160123 Abstract

Development and validation of a high-throughput micro solid-phase extraction method coupled with ultra-high-performance liquid chromatography-quadrupole time-of-flight mass spectrometry for rapid identification and quantification of phenolic metabolites in human plasma and urine. Feliciano RP, Mecha E, Bronze MR, Rodriguez-Mateos A. J Chromatogr A. 2016 Sep 16; 1464:21-31. doi: 10.1016/j.chroma.2016.08.027 Abstract

Identification and quantification of novel cranberry-derived plasma and urinary (poly)phenols. Feliciano RP, Boeres A, Massacessi L, Istas G, Ventura MR, Nunes Dos Santos C, Heiss C, Rodriguez-Mateos A. Arch Biochem Biophys. 2016; 599:31-41.  doi: 10.1016/ Abstract

Urolithins, the rescue of 'old' metabolites to understand a 'new' concept: metabotypes as a nexus between phenolic metabolism, microbiota dysbiosis and host health status. Tomás-Barberán FA, González-Sarrías A, García-Villalba R, Núñez-Sánchez MA, Selma MV, García-Conesa MT, Espín JC. Mol Nutr Food Res. 2016 May 9. doi: 10.1002/mnfr.201500901. Abstract

Resveratrol metabolite profiling in clinical nutrition research--from diet to uncovering disease risk biomarkers: epidemiological evidence. Rabassa M, Zamora-Ros R, Urpi-Sarda M, Andres-Lacueva C. Ann N Y Acad Sci.2015; 1348(1):107-15. doi: 10.1111/nyas.12851 Abstract

The role of metabolism (and the microbiome) in defining the clinical efficacy of dietary flavonoids, Cassidy A and Minihane  AM, Am J Clin Nutr, in press, Abstract

WG2: Inter-individual variation in the biological responsiveness regarding cardiometabolic endpoints

Cocoa flavanol intake improves endothelial function and Framingham Risk Score in healthy men and women: a randomised, controlled, double-masked trial: the Flaviola Health Study. Roberto Sansone, Ana Rodriguez-Mateos, Jan Heuel, David Falk, Dominik Schuler, Rabea Wagstaff, Gunter G. C. Kuhnle, Jeremy P. E. Spencer, Hagen Schroeter, Marc W. Merx, Malte Kelm, Christian Heiss and for the Flaviola Consortium, European Union 7th Framework Program. British Journal of Nutrition 2016 114(08):1246-1255. Abstract

Epigenetic Control of Cardiovascular Health by Nutritional Polyphenols Involves Multiple Chromatin-Modifying Writer-Reader-Eraser Proteins. K. Declerck, K. Szarc vel Szic, A. Palagani, K. Heyninc, G. Haegeman,Ch. Morand, D. Milenkovic and W. Vanden Berghe. Current Topics in Medicinal Chemistry 2016. Abstract

From inflammaging to healthy aging by dietary lifestyle choices: is epigenetics the key to personalized nutrition? K. Szarc vel Szic, K. Declerck, M. Vidakovic, W. Vanden Berghe. Clinical Epigenetics 2015, 7:33. DOI:10.1186/s13148-015-0068-2 Abstract

Flavonoid intake and cardiovascular disease risk. Rodrigo P Feliciano, Sarah Pritzel, Christian Heiss and Ana Rodriguez-Mateos. Current Opinion in Food Science 2015, 2:92–99. DOI:10.1016/j.cofs.2015.02.006 Abstract

Impact of cocoa flavanol intake on age-dependent vascular stiffness in healthy men: a randomized, controlled, double-masked trial. Christian Heiss, Roberto Sansone, Hakima Karimi, Moritz Krabbe, Dominik Schuler, Ana Rodriguez-Mateos, Thomas Kraemer, Miriam Margherita Cortese-Krott, Gunter G. C. Kuhnle, Jeremy P. E. Spencer, Hagen Schroeter, Marc W. Merx,  Malte Kelm. AGE 2015,37:56. DOI:10.1007/s11357-015-9794-9 Abstract

Direct comparison of metabolic health effects of the flavonoids quercetin, hesperetin, epicatechin, apigenin and anthocyanins in high-fat-diet-fed mice. Elise F. Hoek-van den Hil,  Evert M. van Schothorst,  Inge van der Stelt, Hans J. M. Swarts,  Marjanne van Vliet, Tom Amolo,  Jacques J. M. Vervoort, Dini Venema, Peter C. H. Hollman, Ivonne M. C. M. Rietjens,  Jaap Keijer. Genes Nutr 2015,10:23. DOI:10.1007/s12263-015-0469-z Abstract

Citrus flavanones naringenin and hesperetin improve antioxidant status and membrane lipid compositions in the liver of old-aged Wistar rats. Marko Miler, Jasmina Živanović, Vladimir Ajdžanović, Zorana Oreščanin-Dušić, Dragan Milenković, Aleksandra Konić-Ristić, Duško Blagojević, Verica Milošević, Branka Šošić-Jurjević. Experimental Gerontology 84 (2016) 49–60. doi: 10.1016/j.exger.2016.08.014 Abstract

Functional morphology of pituitary -thyroid and -adrenocortical axes in middle-aged male rats treated with Vitex agnus castus essential oil. BrankaˇSoˇsi´c-Jurjevi´, Vladimir Ajdˇzanovi´, Branko Filipovi´, Svetlana Trifunovi´, Ivana Jari´, Nataˇsa Risti´, Verica Miloˇsevi´. Acta Histochemica (2016), DOI: 10.1016/j.acthis.2016.07.007. 

An update on the role of nutrigenomic modulations in mediating the cardiovascular protective effect of fruit polyphenols. I. Krga, D. Milenkovic, C. Morand and L.-E. Monfoulet. Food Funct.,2016, DOI: 10.1039/c6fo00596a.  doi: 10.1039/c6fo00596a Abstract

Histological study of the ovaries from the superovulated mouse supplemented by bioactive feed additive. Vanya Mladenova, Desislava Abadjieva, Elena Kistanova. Journal of Mountain Agriculture on the Balkans, vol. 19, 2, 2016, (23-36).

Cranberry (poly)phenol metabolites correlate with improvements in vascular function: A double-blind, randomized, controlled, dose-response, crossover study.Rodriguez-Mateos A, Feliciano RP, Boeres A, Weber T, Dos Santos CN, Ventura MR, Heiss C. Mol Nutr Food Res. 2016; 60(10):2130-2140. doi: 10.1002/mnfr.201600250 Abstract

WG 3: From emerging science to applications

Analytical Methods - Molybdenum disulphide and graphene quantum dots as electrode modifiers for laccase biosensor. Ioana Vasilescu, Sandra A.V. Eremia*, Mihaela Kusko, Antonio Radoi*, Eugeniu Vasile, Gabriel-Lucian Radu.   Biosensors and Bioelectronics, Volume 75, 15 January 2016, Pages 232-237. Abstract

Other recent articles published by POSITIVe partners with POSITIVe acknowledgement.

Dietary Polyphenols against Metabolic Disorders: How Far Have We Progressed in the Understanding of the Molecular Mechanisms of Action of These Compounds?García-Conesa MT1. Crit Rev Food Sci Nutr. 2017 Jun 13;57(9):1769-1786. doi: 10.1080/10408398.2014.980499.

Gene expression changes in colon tissues from colorectal cancer patients following the intake of an ellagitannin-containing pomegranate extract: a randomized clinical trial. María A. Nuñez-Sánchez, Antonio González-Sarrías, Rocío García-Villalba, Tamara Monedero-Saiz, b, Noelia V. García-Talavera, María B. Gómez-Sánchez, Carmen Sánchez-Álvarez, Ana M. García-Albert, Francisco J. Rodríguez-Gil, Miguel Ruiz-Marín, Francisco A. Pastor-Quirante, Francisco Martínez-Díaz, Francisco A. Tomás-Barberán, Juan Carlos Espín, María-Teresa García-Conesa. Journal of Nutritionnal Biochemistry 2017, 42: 126-133 Abstract

Comprehensive characterization of the effects of ellagic acid and urolithins on colorectal cancer and key-associated molecular hallmarks: MicroRNA cell specific induction of CDKN1A (p21) as a common mechanism involved. Antonio González-Sarrías, María Angeles Núñez-Sánchez, Joao Tome-Carneiro, Francisco A. Tomás-Barberán, María Teresa García-Conesa and Juan Carlos Espín, Mol. Nutr. Food Res.2016, 60, 701–716. doi: 10.1002/mnfr.201500780

In vivo relevant mixed urolithins and ellagic acid inhibit phenotypic and molecular colon cancer stem cell features: A new potentiality for ellagitannin metabolites against cancer. María-Angeles Núñez-Sánchez, Ankur Karmokar, Antonio González-Sarrías, Rocío García-Villalba, Francisco A. Tomás-Barberán, María Teresa García-Conesa, Karen Brown, Juan Carlos Espín, Food and Chemical Toxicology, 92 (2016) 8e16. doi: 10.1016/j.fct.2016.03.011

MicroRNAs expression in normal and malignant colon tissues as biomarkers of colorectal cancer and in response to pomegranate extracts consumption: Critical issues to discern between modulatory effects and potential artefacts. Nuñez-Sánchez MA, Dávalos A, González-Sarrías A, Casas-Agustench P, Visioli F, Monedero-Saiz T, García-Talavera NV, Gómez-Sánchez MB,Sánchez-Álvarez C, García-Albert AM, Rodríguez-Gil FJ, Ruiz-Marín M, Pastor-Quirante FA, Martínez-Díaz F, Tomás-Barberán FA, García-Conesa MT, Espín JC. Mol Nutr Food Res. 2015 Oct; 59(10):1973-86. doi: 10.1002/mnfr.201500357

Association between Both Total Baseline Urinary and Dietary Polyphenols and Substantial Physical Performance Decline Risk in Older Adults: A 9-year Follow-up of the InCHIANTI Study. Rabassa M, Zamora-Ros R, Andres-Lacueva C, Urpi-Sarda M, Bandinelli S, Ferrucci L, Cherubini A. J Nutr Health Aging.2016; 20(5):478-85. doi: 10.1007/s12603-015-0600-2

Association of habitual dietary resveratrol exposure with the development of frailty in older age: the Invecchiare in Chianti study. Rabassa M, Zamora-Ros R, Urpi-Sarda M, Bandinelli S, Ferrucci L, Andres-Lacueva C, Cherubini A. Am J Clin Nutr.2015; 102(6):1534-42. doi: 10.3945/ajcn.115.118976



This article has been corrected to indicate the right COST Action number of POSITIVe


Inhibitory effects of chickpea and Tribulus terrestris on lipase, α-amylase and α-glucosidase. Ercan P, El SN. Food Chem.2016; 205:163-9. doi: 10.1016/j.foodchem.2016.03.012

Corrigendum to "Inhibitory effects of chickpea and Tribulus terrestris on lipase, α-amylase and α-glucosidase" [Food Chem. 205 (2016) 163-169]. Ercan P, El SN. Food Chem. 2016 Oct 1;208:338. doi: 10.1016/j.foodchem.2016.04.062