The 2017 workshop focuses on how all «Omics» (including Nutrigenetics, Nutri(Epi)genomics, Metabolomics and Microbiomics) have helped to provide new findings on the health effects of plant food bioactives. This workshop will deal with scientific findings resulting from the use of these approaches. Both renowned and promising young researchers have been invited and will discuss their most recent scientific findings.
The 3rd Scientific Workshop of POSITIVe will be hosted by Porto Palace Hotel Thessaloniki.
POSITIVe PARTNERS: For additional information regarding the booking of the hotels and any other practical details, please contact directly the local organizers at Christos Kontogiorgis or Antonia Kaltsatou.
Registration fees for COST POSITIVe partners are 20€ (External attendees: 50€)
The Translation of Lipid Profiles to Nutritional Biomarkers in the Study of Infant Metabolism
Albert Koulman (NIHR BRC Nutritional Biomarker Laboratory; NIHR BRC Core Metabolomics and Lipidomics Laboratory; University of Cambridge; UK)
In the first months of life the diet of every infant will consists entirely out of milk, which will be either human breast milk, formula, or both. Many studies have shown that growth, development and disease risk in later life are different between infants starting their life on breast milk or formula. We developed a lipidomics approach that allows us to study lipid metabolism of infants using minimally invasive heel prick samples. With this approach we have been able to show that the lipid metabolism of breast-fed infants is significantly different to those who receive only formula and that some of these differences are associated with growth rates. We have validated key features of the lipid profile as nutritional biomarkers and we are currently trying to understand what part of the milk composition is responsible for these effects and how.
14:50 - 15:20
Biomarkers of food intake and effect after consumption of plant-based dietary patterns in cardiovascular risk participants
Mireia Urpi-Sarda (Barcelona University, Spain)
The consumption of plant-based foods and the adherence to healthy dietary patterns are associated with lower risk of chronic diseases. Their robust measurement is an essential component in studies attempting to establish links between intake or adherence and health outcomes. Currently, they are measured in nutritional epidemiology by the use of questionnaires such as the dietary scores or dietary recalls. We applied metabolomic approaches to study biomarkers of Mediterranean diet adherence and polyphenol-rich food intake. Additionally, these approaches also allowed identifying metabolomic biomarkers of effect of these patterns which could explain altered pathways or metabolic routes involved. The results will provide a better understanding of health benefits of these dietary patterns in nutritional epidemiology.
15:20 - 15:50
Host: microbiome co-metabolic processing of dietary polyphenols – a cross-over study with different doses of apple polyphenols in healthy subjects
Marynka Ulaszewska (Istituto Agrario San Michele all'Adige, Italy)
Human metabolism of apple polyphenols is a co-metabolic process between human encoded activities and those of our resident microbiota. We are delighted to show nutrikinetics study where the aim was to effectively identify the metabolic products of various classes of apple polyphenols using an untargeted metabolomics. We assessed whether particular profiles of apple derived plasma/urine metabolites could be related to individual members of the gut microbiota. Finally we evaluated whether an higher concentration of polyphenols in the apple matrix, would lead to a corresponding increased metabolic output.
15:50 - 16:10
Flash Poster Presentation
Coffee Break and Posters Session
Nutri-genetics, -genomics, and -epigenomics Session (I)
Chairs: Wil Van der Berg (University of Antwerp, Belgium) - Antonio González-Sarrías (CEBAS-CSIC, Spain)
16:40 - 17:20
The impact of genotype on the metabolism and bio-efficacy of plant polyphenols
Anne Marie Minihane (Head of Nutrigenetics and Director of Research and Innovation, Norwich Medical School, University of East Anglia (UEA), Norwich, UK)
At a population level, there is growing evidence of the beneficial effects of plant polyphenols on health. However, there is wide variability in the response to increased intake, which is likely due to heterogeneity in their absorption, distribution, metabolism and elimination (ADME). A number of factors, including age, sex, gut microflora and genotype influence these metabolic process. In this presentation the impact of common gene variants on polyphenol ADME and bio-efficacy will be considered, which may help establish and refine dietary polyphenol intake recommendation for different population subgroups.
17:20 - 17:50
Implications of predictive Genomics for drug response and food intake
George Patrinos (University of Patras, Greece)
Precision medicine aims to interrelate one’s genetic profile with disease predisposition and response to the most commonly used drugs. Nutrigenomics is gradually becoming an important aspect of precision medicine that, contrary to pharmacogenomics that predict drug efficacy and/or toxicity, examines the bidirectional interactions of the genome and nutritional exposures, and attendant health and disease outcomes. However, at present, despite the knowledge gained from nutrigenomics research, integration into the daily clinical practice requires an evidence-based approach to validate that personalized recommendations result in health benefits to individuals and do not cause harm. As (Camp and Trujillo (2014). Stated “…whether or not the knowledge gained from nutrigenomics can be integrated into the everyday lives of consumers is yet unknown”. Here, we will contextualize our recent study of 38 genes included in commercially available nutrigenomics tests and make a call in the best interest of the nutrigenomics science community, governments, global society, and commercial nutrigenomics test providers that new evidence evaluation and synthesis platforms are created concerning nutrigenomics tests before they become commercially available. The proposed assessment and synthesis of nutrigenomics data should be carried out on an ongoing dynamic basis with periodic intervals and/or when there is a specific demand for evidence synthesis, and importantly, in ways that are transparent where conflict of interests are disclosed fully by the involved parties, be they scientists, industry, governments, citizens, social scientists, or ethicists.
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Flash Poster Presentation
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