En naviguant sur notre site vous acceptez l'installation et l'utilisation des cookies sur votre ordinateur. En savoir +

Menu Logo Principal AgroParisTech

MIA Paris

An insight into normal and pathological pregnancies using large-scale microarrays: lessons from microarrays

15 janvier 2013

Chaouat, G. ; Rodde, N. ; Petitbarat, M. ; Bulla, R. ; Rahmati, M. ; Dubanchet, S. ; Zourbas, S. ; Bataillon, I. ; Coqué, N. ; Hennuy, B. ; Martal, J. ; Munaut, C. ; Aubert, J. ; Sérazin, V. ; Steffen, T. ; Jensenius, J. C. ; Foidart, J.-M. ; Sandra, O. ; Tedesco, F. ; Lédée, N.
[Full paper]. 7. International Workshop on Reproductive Immunology, Immunological Tolerance and Immunology of Preeclampsia (2010-08) Tioman Island (MYS). In : 7th International Workshop on Reproductive Immunology, Immunological Tolerance and Immunology of Preeclampsia. (IRL) : Elsevier Ireland Ltd (Journal of Reproductive Immunology, 89), 2011.
Communication avec actes
In the introduction, we briefly recall old but classic evidence that there is no tolerance to paternal alloantigens in a first pregnancy. Therefore, we performed small- and largescale microarrays in CBA×DBA/2 and CBA×BALB/c combinations, recently described as a murine model for preeclampsia. Our results are in line with other data suggesting a very early deregulation of local immune vascular events rather than a break of immune tolerance. Other data presented at the Tioman 2010 Preeclampsia Workshop supporting this hypothesis are briefly summarised, as well as indications and caveats from a recent human microarray on implantation failure and recurrent pregnancy loss.